Outline issues and complications related to paroxysmal nocturnal hemoglobinuria (PNH), and review current and emerging treatment regimens for patients with PNH.
DPYD, TYMS, and MTHFR polymorphisms play a limited role for FU-related toxicity, but a DPYD gene/sex-interaction is predictive for men; mode of administration and folinic acid coadministration are additional predictive factors. Medscape Medical News