DPYD, TYMS, and MTHFR polymorphisms play a limited role for FU-related toxicity, but a DPYD gene/sex-interaction is predictive for men; mode of administration and folinic acid coadministration are additional predictive factors. Medscape Medical News
Increased expression of interleukin-8 is associated with poor clinical outcome in ovarian cancer, and blocking it might offer a new therapeutic approach. Medscape Medical News
For men aged 70 years and older with prostate cancer but without major co-morbidities and who have a life expectancy of at least 10 years, radical retropubic prostatectomy (RRP) is "a real option," a New York investigator told Reuters Health. Reuters Health Information
Members of the consortium will research up to 50 types of cancer, sharing genomic data, research standards, and ethical guidelines. Medscape Medical News