Etanercept may potentially replace corticosteroid therapy for patients with giant cell arteritis (GCA) who are experiencing adverse effects from the corticosteroid, according to the first randomized, double-blind, placebo-controlled trial of etanercept in patients with GCA. Reuters Health Information
A meta-analysis of randomized trials shows modest weight reduction for orlistat, sibutramine, and rimonabant, with differing effects on cardiovascular risk profiles and specific adverse effects. Medscape Medical News
Topiramate therapy can induce profound declines in urinary citrate levels, which may lead to urinary stones, according to a report in the July issue of Urology. Reuters Health Information
Pulmonary absorption of inhaled dihydroergotamine (DHE) mesylate, intended for treatment of acute migraine, produces plasma levels comparable to intravenous administration in healthy individuals, and is well-tolerated, investigators report in the March issue of Headache. Reuters Health Information
Pfizer Inc has won a U.S. court ruling that could limit the lawsuits claiming that its Celebrex painkiller caused heart attacks and strokes. Reuters Health Information
