Dr. Bradley A. Patay discusses several important papers reporting on the relationships of multiple genetic markers to prostate cancer. Medscape Pathology
DPYD, TYMS, and MTHFR polymorphisms play a limited role for FU-related toxicity, but a DPYD gene/sex-interaction is predictive for men; mode of administration and folinic acid coadministration are additional predictive factors. Medscape Medical News
Does tumor vascularity, or expression of vascular endothelial growth factor protein and its receptors, contribute to patient outcomes? Laboratory Investigation