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Other links at Articles > Cardiology |
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First Data on Aliskiren in Diabetic Nephropathy
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The first trial of the new direct renin inhibitor, aliskiren, in patients with diabetic nephropathy shows that it reduces proteinuria when added to conventional treatment. But observers say this is merely a surrogate-end-point trial and definitive guidance on how to use this drug in such patients will come only from an ongoing large outcomes study, ALTITUDE. Heartwire
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A Step Closer to Gene-Guided Warfarin Dosing?
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Another nugget of information with regard to gene-guided dosing of warfarin has been published, with a new prospective study finding that variants in one gene affect the initial response to the drug, but variations in another do not. The results add to the body of knowledge about the pharmacogenetics of warfarin, say editorialists, but this approach is still a way from prime time. Heartwire
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