The vasoactive peptide urocortin 2 (UCN2), a member of the corticotropin-releasing factor (CRF) peptide family, increases left ventricular ejection fraction (LVEF) nearly 15%, researchers report in the November issue of the European Heart Journal. Reuters Health Information
What are the practical implications of a sequential treatment strategy for depression in primary care, with particular reference to the increasingly common problem of recurrent depression? International Journal of Clinical Practice
When imatinib therapy has failed in patients with chronic myelogenous leukemia (CML) in chronic phase, adding the farnesyl transferase inhibitor tipifarnib restores activity against the disease and the combination is relatively well-tolerated, researchers report in the November 1st issue of Cancer. Reuters Health Information
Prophylactic use of a levonorgestrel intrauterine system (LNG-IUS) reduces the occurrence of de novo endometrial polyps in women treated with tamoxifen for breast cancer, according to first-year interim results of a randomized controlled trial. Reuters Health Information
Inadequate analgesic prescriptions and poor patient adherence contribute to ineffective cancer pain management, according to findings published in the November issue of the Journal of Pain and Symptom Management. Reuters Health Information
In patients with obstructive hypertrophic cardiomyopathy, alcohol septal ablation not only reduces the left ventricular outflow tract gradient but also alleviates depression and anxiety and improves quality of life, according to a study published in the November 15 issue of the American Journal of Cardiology. Reuters Health Information
A regimen of lopinavir plus ritonavir (LPV-rtv) alone for three weeks reduces HIV RNA in cerebrospinal fluid (CSF) by a factor of ten in most HIV-infected patients. Reuters Health Information
In women with unruptured ectopic tubal pregnancy, treatment with single-dose rather than multiple-dose methotrexate appears to yield superior results in terms of subsequent tubal patency, according to Turkish researchers. Reuters Health Information
In a murine model of breast cancer, the COX-2 inhibitor celecoxib prevents chronic morphine-induced effects on tumor growth without compromising analgesia, according to researchers. Reuters Health Information
Alemtuzumab is superior to chlorambucil as first-line treatment for patients with chronic lymphocytic leukemia (CLL), according to results of a study published in the December issue of the Journal of Clinical Oncology. Reuters Health Information
