Blocking transforming growth factor (TGF)-beta and downstream Smad2/3 signaling in peripheral macrophages can markedly reduce Alzheimer-like pathology in mice, new research shows. Reuters Health Information
In a murine model of hind-limb ischemia, treatment with sodium nitrite can rapidly enhance ischemia-induced angiogenesis and restore blood flow, according to a report in the May 27th issue of the Proceedings of the National Academy of Sciences. Reuters Health Information
Although B-type natriuretic peptide (BNP) levels are significantly elevated during COPD exacerbation, they are not predictive of subsequent mortality in these patients, according to Swiss researchers. Reuters Health Information
By modifying protease and anti-protease expression, doxycycline prevents alveolar destruction in the VEGF-deficient mouse model of emphysema, according to a report in the May 15th issue of the Journal of Cellular Biochemistry. Reuters Health Information
Heightened levels of the proinflammatory cytokine osteopontin are found in the cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS), according to a paper in the May issue of the Archives of Neurology. Reuters Health Information
Underlying bacterial infection or bacterial toxins may be responsible for some cases of sudden unexpected death in infancy (SUDI), a British research team reports in the May 31 issue of The Lancet. Reuters Health Information
Mutations leading to the premature aging syndrome dyskeratosis congenita are associated with low blood levels of telomerase RNA, confirming the underlying role of shortened telomeres in the condition, according to a report in PNAS Early Edition posted online on June 2. Reuters Health Information
Tumor necrosis factor lambda converting enzyme (TACE) has a role in cancer progression. Is TACE expression involved in endocrine cancers and apoptosis in estrogen receptor positive breast carcinomas? American Journal of Clinical Pathology