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121. PSA-Activated Doxorubicin Prodrug Effective in Prostate Carcinoma Model




A doxorubicin prodrug designed to be cleaved by prostate specific antigen (PSA) is effective in a mouse model of prostate carcinoma, according to a report in the March 1st International Journal of Cancer. Reuters Health Information
Category:   Articles > Pathology and Lab Medicine

Date Added: Mar 21, 2008 Hits: 0 Rating: 0.00 Votes: 0
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122. Growth Protein May Provide New Target for Prostate Cancer




Inhibition of the signal transducer and activator of transcription 5a/b (Stat5a/b), the key mediator of prolactin effects in prostate cancer cells, kills cancer cells and inhibits xenograft growth in mice, researchers report in the March 1st issue of Clinical Cancer Research. Reuters Health Information
Category:   Articles > Pathology and Lab Medicine

Date Added: Mar 21, 2008 Hits: 0 Rating: 0.00 Votes: 0
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123. Potassium Suppresses Free Radicals to Reduce Vascular Injury




Dietary potassium seems to protect against the vascular damage seen with salt-sensitive hypertension, at least in part by suppressing the generation of reactive oxygen species, according to a Japanese study. Reuters Health Information
Category:   Articles > Pathology and Lab Medicine

Date Added: Mar 22, 2008 Hits: 0 Rating: 0.00 Votes: 0
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124. Copolymer-Specific Regulatory T Cells Suppress Autoimmune Diseases in Mice




US researchers have developed regulatory T cells that are capable of suppressing multiple sclerosis and other autoimmune diseases in mice, according to a report in the March 24th Early Edition of the Proceedings of the National Academy of Sciences. Reuters Health Information
Category:   Articles > Pathology and Lab Medicine

Date Added: Mar 26, 2008 Hits: 0 Rating: 0.00 Votes: 0
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125. Genetic Loci Prone to Homozygosity Linked to Carcinomas




Homozygosity at certain "hot spot" gene locations appears to play an important role in cancer susceptibility, scientists at the Cleveland Clinic Foundation report in the Journal of the American Medical Association for March 26. Reuters Health Information
Category:   Articles > Pathology and Lab Medicine

Date Added: Mar 27, 2008 Hits: 0 Rating: 0.00 Votes: 0
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126. Nitric Oxide Enzyme Could Serve as Therapeutic Target for Ras-Related Cancers




New research suggests that endothelial nitric oxide synthase (eNOS) plays a key role in Ras signaling pathways and could serve as a therapeutic target. Reuters Health Information
Category:   Articles > Pathology and Lab Medicine

Date Added: Mar 29, 2008 Hits: 0 Rating: 0.00 Votes: 0
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127. Rare Mutations Impairing Neurodevelopment Implicated in Schizophrenia




New research into the genetic underpinnings of schizophrenia implicates rare mutations that prevent normal brain development, according to a report in the March 27th online issue of Science. Reuters Health Information
Category:   Articles > Pathology and Lab Medicine

Date Added: Mar 29, 2008 Hits: 0 Rating: 0.00 Votes: 0
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128. British Scientists Make Human-Cow Embryos




British researchers say they have created embryos and stem cells using human cells and oocytes of cows, but said such experiments would not lead to hybrid human-animal babies, or even to direct medical therapies. Reuters Health Information
Category:   Articles > Pathology and Lab Medicine

Date Added: Apr 4, 2008 Hits: 0 Rating: 0.00 Votes: 0
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129. APOE-E4 Tied to Improved Long Term Outcome After Brain Injury




In contrast to most prior studies, a new study suggests that carrying the apolipoprotein epsilon 4 (APOE-e4) allele may have a protective influence on long-term outcome following traumatic brain injury. Reuters Health Information
Category:   Articles > Pathology and Lab Medicine

Date Added: Apr 5, 2008 Hits: 0 Rating: 0.00 Votes: 0
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130. Everolimus Overcomes Resistance to EGFR Inhibitors




Inhibition of the mammalian target of rapamycin (mTOR) pathway by everolimus works in concert with epithelial growth factor receptor (EGFR) inhibitors in human tumors both sensitive and resistant to anti-EGFR drugs, according to Italian researchers. Reuters Health Information
Category:   Articles > Pathology and Lab Medicine

Date Added: Apr 10, 2008 Hits: 0 Rating: 0.00 Votes: 0
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