The SATB1 gene reprograms the expression of more than 1000 other genes to facilitate breast cancer growth and metastasis, according to a new report. Reuters Health Information
Offspring of women exposed in utero to diethylstilbestrol (DES) appear to have an increased risk of ovarian cancer, researchers report in the March issue of Epidemiology. Reuters Health Information
In a large Danish birth cohort, neither the frequency nor timing of binge drinking was associated with an increased risk for spontaneous abortion in clinically recognized pregnancies. Medscape Medical News
Most postmenopausal breast cancer patients undergoing neoadjuvant treatment with the nonsteroidal aromatase inhibitor letrozole experience tumor volume reduction within 4 months, according to the findings of a phase IIb/III trial, but no optimal duration of therapy has yet been established. Reuters Health Information
Recent findings published in the March issue of the Archives of Neurology support a maternal parent-of-origin effect in multiple sclerosis. Reuters Health Information
Preimplantation genetic diagnosis (PGD) with an extended panel identifies most cases of aneuploidy in the products of conception in infertile women who have miscarried after embryo transfer, according to a report in the February Fertility and Sterility. Reuters Health Information
In women over 40 years old, pregnancy loss in a first in vitro fertilization (IVF) cycle is not predictive of an improved delivery rate in subsequent cycles, as is the case in women under 40, according to a report in the February issue of Fertility and Sterility. Reuters Health Information
Compared with healthy women, those with rheumatoid arthritis are deficient in vitamin B6 and have elevated levels of homocysteine, which may contribute to the increased risk of cardiovascular events seen with the disease, new research shows. Reuters Health Information
Several methods for evaluating unclassified variants in the breast cancer susceptibility genes BRCA1 and BRCA2 yield similar results, but they are not helpful in predicting individual risk, according to a report in the BMC journal Breast Cancer Research online February 19th. Reuters Health Information
Survivors from Nagasaki and Hiroshima who were 6 years of age or less at the time of the atomic bombings are at increased risk of developing solid cancers. The risk is also increased, but apparently not to the same extent, in survivors who were exposed in utero, researchers report in the March 19th issue of the Journal of the National Cancer Institute. Reuters Health Information
