Thirty of 36 patients with advanced AIDS-related Kaposi sarcoma treated with cyclical pegylated liposomal doxorubicin plus interleukin-12 (IL-12) had a major response to treatment, according to investigators at the National Cancer Institute in Bethesda, Maryland. Reuters Health Information
In this review and commentary: a study of nevirapine (NVP) levels after discontinuation supports continuation of NRTIs for 7 to 10 days after stopping NVP. Medscape HIV/AIDS
This review documents substantial progress surrounding the role of the thymus in HIV infection, including its role in immunopathogenesis during the clinically asymptomatic phase of HIV infection. AIDS
In a study of HIV-infected patients with moderate or severe antiretroviral therapy-induced facial lipoatrophy, injections of poly-L-lactic acid (PLA) produced only modest improvements in objectively assessed facial tissue thickness. However, patients and clinicians perceived significant improvements in facial lipoatrophy severity. Reuters Health Information
In this review and commentary: review of recent results in HIV resistance, including effects of partially suppressive regimens and the importance of adherence to antiretroviral therapy. Medscape HIV/AIDS
In this trial 48 weeks of lopinavir-ritonavir monotherapy with resumption of NRTIs was non-inferior to continuation of 2 NRTIs + lopinavir-ritonavir in patients with prior stable suppression. AIDS
In this review and commentary: Two randomized clinical trials to evaluate whether latex diaphragms or tenofovir preexposure prophylaxis reduce HIV transmission in women. Medscape HIV/AIDS
US researchers have identified a membrane protein that acts as a tether for HIV, preventing the release of virions from infected cells. As it turns out, this protein, which the group named "tetherin," is actually CD317, a previously discovered protein of unknown function. Reuters Health Information
Updated information regarding antiretroviral agents used after HIV exposure for healthcare workers is presented, including new dosages of Kaletra and information regarding Viracept. Morbidity & Mortality Weekly Report
In this review and commentary: A study of the incidence of symptomatic and asymptomatic osteonecrosis using magnetic resonance imaging (MRI) reveals a need for improved prevention and treatment. Medscape HIV/AIDS
