Does tumor vascularity, or expression of vascular endothelial growth factor protein and its receptors, contribute to patient outcomes? Laboratory Investigation
Chemotherapy can improve long-term survival in women with estrogen-receptor-negative breast cancer; results of a meta-analysis found that this was true even for chemotherapy regimens used 20 to 30 years ago. Medscape Medical News
Anecdotal reports suggest that nonsedating antihistamines ease bone pain associated with granulocyte colony-stimulating factor drugs. Does evidence support this practice? Medscape Pharmacists
How do the experts take tumor biology, efficacy and safety data, and patient preferences into account to optimize treatment for metastatic breast cancer? Medscape Hematology-Oncology
Because phase I oncology trials offer relatively little clinical benefit but do carry with them the risk for serious harm, they have been cited as paradigmatic examples of research that exploits vulnerable people. Medscape Medical News
In general, African American women are less likely than white women to pursue genetic testing for BRCA1/2, researchers report. However, African American women with a recent diagnosis of breast cancer are much more likely to do so, according to the article in the January 1st issue of the Journal of Clinical Oncology. Reuters Health Information
In this Expert Interview from SABCS 2007, Dr. William J. Gradishar details the latest novel drug combinations that may benefit patients with advanced breast cancer. Medscape Hematology-Oncology
In older patients with diffuse large B-cell lymphoma, 6 cycles of CHOP-14 with added rituximab improved event-free and overall survival and was as effective as 8 cycles of the same regimen. Medscape Medical News
A 61-year-old man previously treated for prostatic adenocarcinoma was subsequently found to have ductal carcinoma of the prostate. The authors discuss the difficulty of diagnosing and treating this tumor. Nature Clinical Practice Urology
