In older women with early-stage breast cancer, single-agent oral capecitabine was inferior to 2 different conventional chemotherapy regimens. Medscape Medical News
Proteus syndrome is a rare hamartoma syndrome characterized by germline PTEN mutations. How effective is oral rapamycin therapy for its treatment? Nature Clinical Practice Oncology
Research that will affect clinical practice includes a study showing that zoledronic acid reduces relapse in early breast cancer and KRAS mutations predict which patients will respond to cetuximab. Medscape Medical News
Four antiangiogenesis drugs have been approved for human use in solid tumors but no validated biomarkers are available for routine clinical use. The roles and challenges of developing biomarkers of angiogenesis are reviewed. Nature Clinical Practice Oncology
Neurofibromatosis type 2 (NF2) is a tumor suppressor syndrome characterized by schwannomas, meningiomas and spinal cord gliomas. The clinical features, diagnostic criteria, presentations and treatment of NF2 are reviewed in this case. Nature Clinical Practice Oncology
Finasteride does not appear to increase the risk for high grade prostate tumors when used as a chemopreventive agent, and appears to be highly effective in reducing the incidence of prostate cancer in high-risk men. Medscape Medical News
Several new agents are showing activity in refractory thyroid cancer, suggesting that a treatment paradigm shift is "not far off." Medscape Medical News
