Modifying the mouse Cebpa locus to mimic the most common mutations of the human CEBPA gene leads to genetically altered mice that develop acute myeloid leukemia (AML) with complete penetrance. Reuters Health Information
Dr. Maurie Markman describes the somewhat controversial work of investigators who explored the relative role of chemotherapy vs. pelvic radiation in intermediate- or high-risk endometrial cancer. Medscape Hematology-Oncology
Gemcitabine, in combination with platinum analogs or fluoropyrimidines, improves survival in patients with advanced pancreatic cancer, according to results of a meta-analysis reported in the March 28th issue of BMC Cancer. Reuters Health Information
In women with a certain genotype, tamoxifen is as effective as — or more effective than — aromatase inhibitors in reducing the risk for breast cancer relapse. Medscape Medical News
Members of the consortium will research up to 50 types of cancer, sharing genomic data, research standards, and ethical guidelines. Medscape Medical News
In women with early-stage, hormone receptor-positive breast cancer, extended therapy with the steroidal aromatase inhibitor exemestane after 5 years of treatment with tamoxifen significantly improves relapse-free survival, according to an analysis of the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-33 trial. Reuters Health Information
For men aged 70 years and older with prostate cancer but without major co-morbidities and who have a life expectancy of at least 10 years, radical retropubic prostatectomy (RRP) is "a real option," a New York investigator told Reuters Health. Reuters Health Information
