In postmenopausal women with hormone receptor-positive breast cancer, letrozole suppresses plasma estradiol and estrone sulfate more completely than does anastrozole, according to UK researchers. Reuters Health Information
Mutations in the gene (DEHAL1) encoding iodotyrosine deiodinase in the thyroid cause severe hypothyroidism that can retard neurological development if not detected and treated early, Dr. Jose C. Moreno and colleagues report in The New England Journal of Medicine for April 24. Reuters Health Information
Pyruvate kinase deficiency, the second most common red blood cell enzyme disorder, protects against infection and replication of Plasmodium falciparum, according to a report in The New England Journal of Medicine for April 24. Reuters Health Information
In children and adolescents with type 1 diabetes, consumption of a low glycemic index diet may reduce glucose excursions and improve overall glycemic control, according to results of a National Institutes of Health-sponsored study. Reuters Health Information
Targeting both low density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol is necessary to achieve the lowest possible risk of atherosclerosis progression, according to results of a meta-analysis of three large, randomized, controlled trials. Reuters Health Information
A retrospective study shows that the prevalence of diabetes before pregnancy is high, with greater health risks to mother and baby than gestational diabetes, which occurs in 8% of pregnancies. Medscape Medical News
The panelists in this video discussion -- a urologist, an endocrinologist, and a primary care physician -- discuss controversial issues surrounding late-onset male hypogonadism. Medscape Urology
Baseline levels of adiponectin are inversely related to diabetes risk in subjects at high risk for developing the condition, researchers report in the April issue of Diabetes. Reuters Health Information
Two studies released Tuesday report the identification of several genetic variants that influence the risk of osteoporosis and fractures. Reuters Health Information
A study shows that the Diabetes Risk Calculator, a paper-based screening tool, determines and detects both prediabetes and undiagnosed diabetes in the US population. Medscape Medical News