A meta-analysis of three genome-wide association studies, followed by replication testing in a large independent sample, has identified six previously unknown loci associated with type 2 diabetes. The combined analysis included more than 89,000 people and about 2.2 million single nucleotide polymorphisms (SNPs). Reuters Health Information
Everyone seems to agree that there is little in the ONTARGET megatrial to quibble about and that it shows clear results. Discussion has revolved around how the initial choice between an ACE inhibitor and angiotensin receptor blocker should now be made. Heartwire
An increase in energy intake is likely the greatest contributor to weight gain when starting insulin therapy, researchers suggest based on a study they conducted in a group of diabetic adults. Reuters Health Information
Poor glycemic control is linked to development of microalbuminuria in childhood-onset type 1 diabetes, and the risk for progression to macroalbuminuria is similar to that in adult-onset disease. Medscape Medical News
The use of antidepressant medication is strongly associated with the risk of developing diabetes, according to findings published in the March issue of Diabetes Care. Reuters Health Information
A review provides a description of metabolic disorders included in expanded newborn screening programs, recommended practices, and other resources for primary care clinicians. Medscape Medical News
In a longitudinal study, patients who slept for short or long durations experienced an increase in weight vs those who slept for an average duration of 7 to 9 hours. Medscape Medical News
Identifying women with osteoporosis at high risk of fractures determines which drug therapy is effective at reducing fracture risk. Patient- and drug related determinants of initiating pharmacotherapy for fracture prevention are reviewed. Nature Clinical Practice Rheumatology
Subtenon injection of triamcinolone acetonide is a reasonable alternative to intravitreal injection for the treatment of cystoid diabetic macular edema, according to a March 17th report published by BMC Ophthalmology. Reuters Health Information
Postmenopausal use of conjugated equine estrogen (CEE) at a dose of 0.625 mg/day appears to increase the risk of benign proliferative breast disease, according to a report in the Journal of the National Cancer Institute for April 16. Reuters Health Information