Our understanding of melanoma at the molecular level has blossomed with the advent of genomic technologies. In this review, the authors consider some of the clinical implications of these genetic findings for both diagnostics and therapeutics. The British Journal of Dermatology
Results of a study published in the August issue of Chest suggest that yellow nail syndrome is an acquired disorder in the majority of cases. Associated respiratory manifestations in this population are usually manageable with medical and surgical treatments. Reuters Health Information
Aggressive corticosteroid therapy does not differ from standard therapy in improving outcomes of patients with juvenile dermatomyositis, according to findings published in the July 15th issue of Arthritis and Rheumatism (Arthritis Care and Research). Reuters Health Information
Although the survival rate of melanoma with metastases to the central nervous system is dismal, new medications, such as ipilimumab, offer hope to these patients. Nature Clinical Practice Oncology
Facial transplantation can be a useful treatment for severe disfigurement, although it is not without risks, according to two case reports involving facial damage caused by a bear attack and by growth of a rare aggressive tumor. Both reports appear in the August 23rd issue of The Lancet. Reuters Health Information
Quality of life in patients with vitiligo is strongly impaired. This study investigates the physical and psychological affects of vitiligo, using patient questionnaires. The British Journal of Dermatology
Researchers describe adverse dermatologic effects in the scrotal and inguinal areas in 5 of 40 patients taking sunitinib for renal cell carcinoma. Medscape Medical News
Three cases linking tumor necrosis factor (TNF)-alpha antagonist therapy with the development of psoriasiform lesions are reported in the current online edition of the Annals of the Rheumatic Diseases. Reuters Health Information
Persons with a history of nonmelanoma skin cancer are at an increased risk for the development of subsequent noncutaneous cancer vs the general population. Medscape Medical News
