The simpler strategy of controlling ventricular rate and allowing atrial fibrillation to persist was probably better than the more complex rhythm control. Medscape Medical News
In the Canadian SMART study, no safety concerns were noted about using large doses of candesartan cilexetil to treat proteinuria. Medscape Medical News
Using genetic tests improved the accuracy and efficiency of warfarin dose initiation in the Couma-Gen study, but the primary end point of a reduction in out-of-range INRs was not significantly changed. Heartwire
Prasugrel reduced ischemic events vs clopidogrel, but increased major (and fatal) bleeding in patients with acute coronary syndromes scheduled for percutaneous coronary intervention. Medscape Medical News
Two new studies on the association between preeclampsia and cardiovascular disease strengthened previous findings in that women with preeclampsia have a higher risk for cardiovascular disease. Medscape Medical News
The predominant view on the trial appears to be that prasugrel probably does have a role in clinical practice, as long as care is taken in certain patient groups at high risk of bleeding. Heartwire
AstraZeneca has gained an additional indication in the US for rosuvastatin, as an adjunct to diet to slow the progression of atherosclerosis in patients with elevated cholesterol. Doctors will now have the option of prescribing rosuvastatin to those with a 10-year Framingham risk of less than 10%; such patients usually just receive advice on lifestyle interventions. Heartwire
